Repression of Human Telomerase Reverse Transcriptase Using Artificial Zinc Finger Transcription Factors
نویسندگان
چکیده
منابع مشابه
Repression of human telomerase reverse transcriptase using artificial zinc finger transcription factors.
Telomerase activation is a key step in the development of human cancers. Expression of the catalytic subunit, human telomerase reverse transcriptase (hTERT), represents the limiting factor for telomerase activity. In this study, we have used artificial zinc finger protein (ZFP) transcription factors (TF) to repress the expression of hTERT in human cancer cell lines at the transcriptional level....
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2010
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-09-0141